1. Immersion method: configure a 10% concentration of film solution, that is, the ratio of film to water is 1:9.
⑴Ordinary film:
(a) Opening at room temperature: soak in tap water at room temperature (25℃), first add a certain amount of water to the beaker, and then evenly and slowly sprinkle the film in, while gently shaking the beaker to make the film evenly dispersed in the water, respectively Record the dissolution in 1 hour, 7 hours, and 24 hours;
(b) Hot water boiling: soak in tap water at 45°C and 60°C and heat it in a water bath to keep it warm. Visually record the dissolution for 1 hour, 4 hours, and 6 hours, respectively.
⑵Instant-dissolving film: Sprinkle 10g of the instant film evenly into 90ml tap water, while gently shaking the beaker to disperse the film evenly in the water, soak it at room temperature for 60min, and observe the dissolution.
2. Stirring method: the opening concentration is 10%, that is, the ratio of the film to the water is 1:9. First add a certain amount of cold water to the beaker, sprinkle the film evenly and slowly at a stirring speed of about 300 rpm, and then slowly raise the temperature to 60 ℃, 80 ℃ (non-ionic film 75 ℃), and continue to stir for 60 minutes with an electric mixer (non-ionic film 75 ℃). Ion film 30min), record the dissolution. Note: During hot water immersion and stirring method, the higher temperature and longer time will cause more water to evaporate. After observing the solubility, if you use the film liquid as the working fluid, you should add water. Make it into a soft tablet solution with a concentration of 10%. The specific method can be pre-weighed before cutting, and after the operation is completed, the reduced weight of water can be added.
3. Description of the dissolution situation: Generally, it is described in text. When the number of films is large and the test items are more comprehensive, and the text description is more cumbersome, you can consider using a code to indicate it, but you must specify it first. The corresponding text and code are as follows: Code Dissolution 1 Basically no swelling 2 Small part swelling 3 Most swelling, a small amount of dissolution 4 Mostly dissolving 5 Mostly dissolving 6 Completely dissolving Remarks: If the film dissolves into a thick and uneven shape, use an underline Mark N.
4. Simple determination of solubility: Take about 1 gram of the opened soft tablet solution and put it in 100 mL of water and stir to observe whether there is any soft tablet particles. If there is, it means that the film is not completely dissolved, so continue to stir until it is completely dissolved.